Faculty: General Surgery
Timothy J. Kieffer, Ph.D.
Professor
Departments of Cellular & Physiological Sciences and Surgery
Laboratory of Molecular and Cellular Medicine
5308 - 2350 Life Sciences Centre
University of British Columbia
Vancouver, B.C. V6T 1Z3
Phone: 604.822.2156
Fax: 604.822.6048
Email: tim.kieffer@ubc.ca
Projects
- Meal-Regulated Insulin Secretion from Gut K-Cells
- Conversion of Gut Stem Cells to Beta-Cells
- Leptin Regulation of Glucose Homeostasis
- GLP-1 Gene Therapy for Diabetes
Selected Publications
Laubner K, Kieffer TJ, TLam NT, Jacob F & Seufert J :
Leptin mediated signal transduction and preproinsulin gene regulation in pancreatic beta cells involves suppressor of cytokine signaling 3 (SOCS3). Diabetes (in press)
Nyberg J, Anderson MF, Meister B, Alborn A-M, Ström A-K, Brederlau A, Illerskog A-C, Nilsson O, Kieffer TJ, Ricksten A & Eriksson PS :
Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. J. Neurosci. 25:1816-1825 (2005)
Stock S, Leichner P, Wong ACK, Ghatei MA, Kieffer TJ, Bloom SR & Chanoine J-P. Ghrelin, PYY :
GIP and hunger responses to a mixed meal in anorexic, obese and control female adolescents. J. Clin. Endorinol. Metab. 90:2161-2168 (2005)
Lam NT, Lewis JT, Cheung AT, Luk LT, Wang J, Kolls JK, and Kieffer TJ :
Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase-1B expression. Mol. Endocrinol. 18:1333-1345 (2004)
Fujita Y, Cheung AT, and Kieffer TJ :
Harnessing the gut to treat diabetes. Pediatr. Diabetes 5 Suppl. 2:57-69 (2004)
Cheung AT, and Kieffer TJ :
Harnessing the gut to treat diabetes. Pediatr. Diabetes 5 Suppl. 2:57-69 (2004)
Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Boylan MO, Wolfe MM, and Kieffer TJ :
Glucose-dependent insulin release from genetically engineered K cells. Science 290:1959-1962 (2000)
Kieffer TJ and Habener JF :
The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am. J. Physiol. 278:E1-E14 (2000)
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, and Egan JM :
Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49:741-748 (2000)
Lewis JT, Dayanandan B, Habener JF, and Kieffer TJ :
Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology 141:3710-3716 (2000)
Seufert JR, Kieffer TJ, and Habener JF :
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc. Natl. Acad. Sci. USA 96:674-679 (1999)
Kieffer TJ and Habener JF :
The glucagon-like peptides. Endocr. Rev. 20:1-38 (1999)
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